Getting High Blood Pressure Under Control

Monday, March 1, 2010

Getting High Blood Pressure Under Control (NAPSA)—High blood pressure is one of the most common medical conditions in the U.S., affect- ing about one in three American adults.t The condition has no specific symptoms, and can remain undetected for many years, increasing the risk of heart, brain and kidney related diseases such as stroke, heart attack, heart and kidney failure.’ In fact, it is estimated that more than 22 percent of people with high blood pressure in the U.S. are not aware they have the condition.’ Detection Is Key The impact of high blood pressure is influenced by both gender and age. Up until age 45, more men than women have it, but the pendulum then swings back to the center from ages 45 to 54, where the percentages of men and women afflicted with high blood pressure are similar. After age 54, a much higher percentage of women have high blood pressure than men." The cause of 90 to 95 percent of the cases of high blood pressure isn’t known. However, once it is detected, it is usually controllable.: If you have been diagnosed with high blood pressure, it is important for you and your doctor to work together to bring it under control. Steps You Can Take The good newsis that there are a number of things you can do about it, including the following’: Eat a healthy diet and limit salt intake Participate in regular physical activity Maintain a healthy weight Reducestress Avoid smoking Limit alcohol consumption Eight Ways to Manage Your Blood Pressure* Fata healthy diet and limit salt intake Participate in regular physical activity Maintain a healthy weight Reducestress Avoid smoking Limit alcohol consumption Discuss appropriate prescription treatment options with your doctor Know your blood pressure and work to keep it at the appropriate goal @ Discuss appropriate prescription treatment options with your doctor Know your blood pressure and work to keep it at appropriate levels. Medication Can Help Because high blood pressure is a “silent” condition, proper managementis critical, however, it is often challenging to keep it at the recommended blood pressure goal of 140/90 mm Hg or 130/80 mm Hg for those with certain chronic health conditions, such as dia- betes or kidney disease.?* Sometimes diet and exercise alone are not enough, and medical intervention is needed. Morethan half of people taking current blood pressure—lowering therapies do not reach recommended blood pressure goals.* According to experts, most patients with high blood pressure will need to take two or more antihypertensive medications to achieve their blood pressure goal.’ Fixed-dose combination therapies have becomeincreasingly popular as effective treatment options to lower blood pressure within the medical community.** In fact, a new combination product, TRIBENZOR™ (olmesartan medoxomil, amlodipine, hydrochlorothiazide), was recently approved by the U.S. Food and Drug Administration (FDA) for the treatment of hypertension. It is not indicated for initial therapy. It combines three widely prescribed antihypertensive medications, each working in a different way, to lower blood pressure to help patients reach their goal’: olmesartan medoxomil (the active ingredient in Benicar, which blocks angiotensin II receptors), amlodipine (which blocks the entrance of calcium into the blood vessel walls), and hydrochlorothiazide (a diuretic which reduces water volume in the blood).’ Together these three medications allow blood vessels to relax so that blood can flow more easily.7 The convenience of three effective medications in one product may help provide people with a simple and convenient treatment option. But as always, it’s important for people with hypertension to speak with their doctor about establishing an appropriate treatment regimen that includes diet, exercise and, if necessary, the proper medication. The most common adverse reactions (incidence >2 percent) seen in clinical trials for TRIBEN- ZOR were dizziness, peripheral edema, headache, fatigue, naso- pharyngitis, muscle spasms, nau- sea, upper respiratory tract infection, diarrhea, urinary tract infection, and joint swelling. For more information about TRIBENZOR, including full pre- scribing information, please visit www.tribenzor.com. at htp:/ /www.ameri 1 American Heart A High Blood Pressure istics. A org |presenter,jhimi identifi =4621 A d on June 29, 2010. h, 2 American Heart Association. Discover Why High Blood Pressure Matters. Available at htip:/ / www.ameri .org |presenterjhimltid ifier=2129 A d on June 29, 2010. 3 American Heart Association. Heart Disease and Stroke Statistics: 2007 Update At-A-Glance, p. 20. Available at: htp:/ / www.americanheart.org /downloadable/ heart / 1166712318459HS_StatsInsideText.pdf. Accessed June 22, 2010. h, 4 American Heart Association. Prevent and Treat High Blood Pressure. Availableat: hitp:/ /www.ameri org /presenterjhimitid ifier=2133. A don June 29, 2010. 5 U.S. Department ofHealth and Human Services, National Institutes ofHealth, National Heart, Lung, and Blood Institute. The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment ofHigh Blood Pressure. NIH Publication No. 04-5230. August 2004. 6 Gupta AK, et al. Compliance, Safety, and Effectiveness ofFixed-Dose Combinations ofAntihypertensive Agents: A Meta-Analysis. Hypertension. 2010;55;399-407. 7 Datichi Sankyo, Inc.. TRIBENZOR Prescribing Information. Note to Editor: IMPORTANT SAFETY INFORMATION ABOUT TRIBENZOR. WARNING: AVOID USE IN PREGNANCY When pregnancyis detected, discontinue TRIBENZORas soonas possible. Drugs that act directly on the renin-angiotensin system can cause injury and even death to the developing fetus. See WARNINGS AND PRECAUTIONS.Fetal/Neonatal Morbidity and Mortality. Contraindications TRIBENZORis contraindicated in patients with anuria or hypersensitivity to other sulfonamide-derived drugs. Hypotension in Volume- or Salt-Depleted Patients In patients with an activated renin-angiotensin system, such as volume- and/or salt-depleted patients, symptomatic hypotension due particularly to the olmesartan component may occur after initiation of treatment with TRIBENZOR. Treatment should start under close medical supervision. Increased Angina and MyocardialInfarction Patients, particularly those with severe obstructive coronary artery disease, may develop increased frequency, duration, or severity of angina or acute myocardial infarction on starting calcium channel blocker therapy or at the time of dosage increase. Impaired Renal Function Avoid use in patients with severely impaired renal function (creatinine clearance

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